Lung lesions of TB variable, independent, whether infection is active or latent
For the complete article, click here.
When the lungs become infected with M. tuberculosis, the body's immune system walls off the bacteria into lesions called granulomas, explained co-senior investigator JoAnne Flynn, Ph.D., professor of microbiology and molecular genetics, Pitt School of Medicine.
"It's long been thought that the patient with a weakened immune system or some other immune vulnerability was more likely to develop active disease," Dr. Flynn said. "But to our surprise, our study showed that every infected individual has a collection of granulomas, some containing live bacteria and some that are sterile because the immune system has killed all the bacteria. So in this sense, there's no such thing as a latent or active granuloma."
This was a study done by Sarah Fortune, M.D. (et. al), of Harvard University, funded in part by the Bill & Melinda Gates Foundation.
Not such good news.